Therefore, brethren, we were comforted over you in all our affliction and distress by your faith:

Therefore we were comforted, brethren, in you, in all our necessity and tribulation, by your faith,

for this reason we have been comforted in you, brethren, in all our distress and tribulation, through your faith,

because of this we were comforted, brethren, over you, in all our tribulation and necessity, through your faith,

for this reason in our distress and trouble we have been comforted about you, brethren, by your faith.

As a result, we were consoled in you, brothers, in the midst of all our difficulties and tribulations, through your faith.

on hearing this, we felt encouraged about you, friends, in the midst of all our difficulties and troubles, by your faith.

We were comforted over you - See the notes, 2-Corinthians 1:3-7; 2-Corinthians 7:6-7. The sense here is, that their steadfastness was a great source of comfort to him in his trials. It was an instance where the holy lives and the fidelity of a people did much, as will always be the case, to lighten the burdens and cheer the heart of a minister of the gospel. In the inevitable trials of the ministerial office there is no source of comfort more rich and pure than this.

Therefore - we were comforted - My afflictions and persecutions seemed trifles when I heard of your perseverance in the faith.

Therefore, brethren, we were comforted over, you,.... Or "in you", as the Vulgate Latin version; or "from you", as the Arabic; or "by you", as the Syriac; or "for you", as the Ethiopic; that is, on account of them, either by what they had heard was in them, or had heard from them. This gave abundant consolation
in all our affliction and distress: which they met with at Corinth, where the apostle laboured with his own hands, and ministered to his own, and the necessities of others, and was greatly opposed, reproached, and persecuted; see Acts 18:3, but the news of the good estate and condition the Thessalonians were in, was a great relief and comfort to him, particularly their faith:
by your faith: by the report of it, that it grew exceedingly, and that they walked in the truth; see 1-John 5:4. The Alexandrian copy reads, "in all your distress and affliction, and by your faith."

over you--in respect to you.
in--in the midst of: notwithstanding "all our distress (Greek, 'necessity') and affliction," namely, external trials at Corinth, whence Paul writes (compare 1-Thessalonians 3:6, with Acts 18:5-10).