Forsake me not, O Lord - That is, Do not leave me in my troubles, my sickness, my sorrow. Leave me not to die; leave me not to complain and dishonor thee; leave me not to the reproaches of my enemies.
O my God, be not far from me - See Psalm 35:22. Compare Psalm 10:1; Psalm 13:1.

Forsake me not, O Lord - Though all have forsaken me, do not thou.
Be not far from me - Though my friends keep aloof, be thou near to help me.

Forsake me not, O Lord,.... Or continue not to forsake; for he seems to have been under divine desertion, and might be under apprehensions that God had utterly forsaken him; which he entreats he would not, though his friends had forsook him, and his own strength had failed and left him, Psalm 38:10;
O my God, be not far from me; as to his gracious presence, and with respect to help and deliverance, otherwise God is not far from any of his creatures, being omnipresent.

(Compare Psalm 22:19; Psalm 35:3). All terms of frequent use. In this Psalm the language is generally susceptible of application to Christ as a sufferer, David, as such, typifying Him. This does not require us to apply the confessions of sin, but only the pains or penalties which He bore for us.