For what is a man advantaged, if he gain the whole world, and lose himself, or be cast away?

For what is a man profited, if he gain the whole world, and lose or forfeit his own self?

For what is a man advantaged, if he gain the whole world, and lose himself, and cast away himself?

For what shall a man profit if he shall have gained the whole world, and have destroyed, or come under the penalty of the loss of himself?

for what is a man profited, having gained the whole world, and having lost or having forfeited himself?

Why, what benefit is it to a man to have gained the whole world, but to have lost or forfeited his own self.

For what profit will a man have if he gets all the world, but undergoes loss or destruction himself?

For how does it benefit a man, if he were to gain the whole world, yet lose himself, or cause himself harm?

What good does it do someone if, when they has gained the whole world, they has lost or forfeited themselves?

Lose himself - That is, his life or soul. See the parallel places, Matthew 16:25 (note); Mark 8:35 (note), and especially the note on the former.
Or be cast away? - Or receive spiritual damage η ζημιωθεις. I have added the word spiritual here, which I conceive to be necessarily implied. Because, if a man received only temporal damage in some respect or other, yet gaining the whole world must amply compensate him. But if he should receive spiritual damage - hurt to his soul in the smallest degree, the possession of the universe could not indemnify him. Earthly goods may repair earthly losses, but they cannot repair any breach that may be made in the peace or holiness of the soul. See on Matthew 16:26 (note).

For what is a man advantaged if he gain the whole world,.... Or what profit will it be unto him? all the honours, riches, and enjoyments of it will be of no use and service to him if he himself is lost:
and lose himself; or his own soul; for he that loses his soul, which is his better and immortal part, loses himself:
or be cast away: finally, and eternally, or "suffer loss" of eternal happiness and glory; that is, perishes, and is destroyed with an everlasting destruction; See Gill on Matthew 16:26.