But from the beginning of the creation,.... Of the world, or of man: , "from the beginning of the creation of the world", is a way of speaking often used by the Jews (r): the phrase "of the creation" is left out in the Syriac and Persic versions; and so it was in Beza's most ancient copy, and it is only read, "from the beginning", as in Mat_19:4,8; see Gill on Matthew 19:4, See Gill on Matthew 19:8.
God made them male and female; the first that were created, Adam and Eve, the first parents of mankind, the first couple that came together were one male and one female; so that there could be no polygamy or divorce: Adam could not have more wives than one: nor could he put away Eve, and marry another; no provision was made for any such usages and practices; See Gill on Matthew 19:4. In the Complutensian edition, it is added, "and said", the following words.
(r) Bereshit Rabba, sect. 3. fol. 2. 3. & sect. 4. fol. 4. 1.

From the beginning of the creation - Therefore Moses in the first of Genesis gives us an account of things from the beginning of the creation. Does it not clearly follow, that there was no creation previous to that which Moses describes? God made them male and female - Therefore Adam did not at first contain both sexes in himself: but God made Adam, when first created, male only; and Eve female only. And this man and woman he joined together, in a state of innocence, as husband and wife.