Simon the Canaanite - Luke calls him "Simon Zelotes," the zealous. It is probable that he was one of a small sect of the Jews called "Zealots," on account of special zeal in religion. His native place was probably "Cana." Afterward he might with propriety be called by either title.
Judas Iscariot - It is probable this name was given to him to designate his native place. Carioth was a small town in the tribe of Judah.

Simon - He was third son of Alpheus, and brother of James and Jude, or Judas, Matthew 13:55.
The Canaanite - This word is not put here to signify a particular people, as it is elsewhere used in the Sacred Writings; but it is formed from the Hebrew קנא kana, which signifies zealous, literally translated by Luke, Luke 6:15, ζηλωτης, zelotes, or the zealous, probably from his great fervency in preaching the Gospel of his Master. But see Luke 6:15.
Judas Iscariot - Probably from the Hebrew איש קריות ish kerioth, a man of Kerioth, which was a city in the tribe of Judah, Joshua 15:25, where it is likely this man was born.
As אסכרא iscara, signifies the quinsy, or strangulation, and Judas hanged himself after he had betrayed our Lord, Dr. Lightfoot seems inclined to believe that he had his name from this circumstance, and that it was not given him till after his death.
Who also betrayed him - Rather, even he who betrayed him, or delivered him up; for so, I think, ο και παραδους αυτον should be translated. The common translation, who Also betrayed him, is very exceptionable, as it seems to imply, he was betrayed by some others, as well as by Judas.

Simon the Canaanite, and Judas (b) Iscariot, who also betrayed him.
(b) A man of Kerioth. Now Kerioth was in the tribe of Judah; (Joshua 15:25).

Simon the Canaanite, and Judas Iscariot,.... This is the last couple, for they are all mentioned by pairs, because they were sent forth "by two and two", as the Evangelist Mark says, Mark 6:7. The former of these is called Simon the Canaanite, to distinguish him from Simon Peter, before mentioned; not that he was a Canaanite, that is, an inhabitant of the land of Canaan, a man of Canaan, as a certain woman is called a woman of Canaan, Matthew 15:22 for all the disciples of Christ were Jews; though in Munster's Hebrew Gospel he is called , "Simeon the Canaanite", or of Canaan, as if he belonged to that country; nor is he so called from Cana of Galilee, as Jerorm and others have thought; but he was one of the "Kanaim", or "Zealots"; and therefore Luke styles him, "Simon called Zelotes", Luke 6:15. The Kanaites, or Zelotes, were a set of men, who, in imitation of Phinehas, who slew Zimri and Cozbi in the very act of uncleanness, when they found any persons in the act of adultery, idolatry, blasphemy, or theft, would immediately kill them without any more ado: this they did, from a pretended zeal for the honour and glory of God: nor were they accountable to any court of judicature for it; yea, such an action was highly applauded, as a very laudable one (z): under this specious name of Zealots, innumerable murders, and most horrible wickedness were committed, both before, and during the siege of Jerusalem, as Josephus (a) relates. Now Simon was one of this sect before his conversion, and still retained the name afterwards. Judas, the last of the twelve, is called Iscariot; concerning which name, the notation of it, and the reason of his being so called, many are the conjectures of learned men: some think that he belonged to the tribe of Issachar, and that he is called from thence, , "a man of Issachar", as a certain man is, in Judges 10:1 others, that he takes his name from the place he belonged to, and that he was called , "a man of Kerioth". A place of this name is mentioned, Joshua 15:25 and some manuscripts and copies in some places read Judas , of "Caryot". Caryota is said (b) to be a plain of the city of Jericho, about eighteen miles from Jerusalem, which abounded in palm trees, called "Caryotae", of which mention is made in the (c) Talmud, and other writers (d). Others think he is so called, from the Syriac word, "secariota", which signifies a "purse", or bag, because he carried the bag. Some copies read it, "scariotes": others are of opinion, that he is so called, from the manner of death he died, which was strangling: for "ascara", a word often used in the (e) Talmudic writings, signifies "strangling"; and is accounted by the Jews the hardest of deaths, and an evil one; and which seems to bid fair for the true reason of his name: however, it is mentioned here, as elsewhere, to distinguish him from Jude, or Judas, the true and faithful apostle of Christ; for this was he,
who also betrayed him; that is, Christ, as the Persic version reads it; and which is mentioned, not only for further distinction's sake, but to his great reproach. We learn from hence, that in the purest society on earth there has been an impure person; nor can it therefore be expected it should be otherwise in the best of churches, in the present state of imperfection; yea, that a man may have the highest gifts and attainments, as Judas had, ministerial gifts, and power of performing miracles, and yet be a vile person.
(z) Misn. Sanhedrim, c. 9. sect. 6. & Bartenora, in ib. T. Avoda Zara, fol. 36. 2. Maimon. Issure Bia, c. 12. sect. 4, 5, 6. 14. & Sanhedrim, c. 18. sect. 6. & Obede Cochabim, c. 2. sect. 9. Philo de Monarchia, l. 1. p. 818. (a) De Bello Jude. l. 5. c. 1, 2. & 6. 1. Vid. Abot R. Nathan, c. 6. fol. 3. 2. (b) Vid. Wolfi Hebrews. Bibl. p. 410. (c) T. Bab. Beracot, fol. 50. 2. & Avoda Zara, fol. 14. 2. (d) Plin. Nat. Hist. l. 13. c. 4. (e) T. Bab. Beracot, fol. 8. 1. & Sabbat, fol. 33. 1. Sota, fol. 35. 1. Pesachim, fol. 105. 1. Taanith, fol. 19. 2. & 27. 2. Yebamot, fol. 62. 2.

Simon the Canaanite--rather "Kananite," but better still, "the Zealot," as he is called in Luke 6:15, where the original term should not have been retained as in our version ("Simon, called Zelotes"), but rendered "Simon, called the Zealot." The word "Kananite" is just the Aramaic, or Syro-Chaldaic, term for "Zealot." Probably before his acquaintance with Jesus, he belonged to the sect of the Zealots, who bound themselves, as a sort of voluntary ecclesiastical police, to see that the law was not broken with impunity.
and Judas Iscariot--that is, Judas of Kerioth, a town of Judah (Joshua 15:25); so called to distinguish him from "Judas the brother of James" (Luke 6:16).
who also betrayed him--a note of infamy attached to his name in all the catalogues of the Twelve.

Iscariot - So called from Iscarioth, (the place of his birth,) a town of the tribe of Ephraim, near the city of Samaria.