There is none to guide her among all the sons whom she hath brought forth; neither is there any that taketh her by the hand of all the sons that she hath brought up.

There is none that can uphold her among all the children that she hath brought forth: and there is none that taketh her by the hand among all the children that she hath brought up.

there is none to guide her among all the children that she hath brought forth; neither is there any to take her by the hand of all the children that she hath brought up.

There is not a leader to her Out of all the sons she hath borne, And there is none laying hold on her hand Out of all the sons she hath nourished.

She has no one among all her children to be her guide; not one of the sons she has taken care of takes her by the hand.

There is no one who can uphold her, out of all the sons whom she has conceived. And there is no one who would take her by the hand, out of all the sons whom she has raised.

Non est qui regat eam ex omnibus illils quos genuit; non est qui apprehendat manum ejus ex onmibus illils quos educavit.

There is no one to guide her. He describes the sorest calamity of the Church; for the heaviest and sorest of all undoubtedly is, that she receives no sympathy or consolation from her own children. This accumulated misery is described by him, in order that, though her condition be desperate, she may still expect consolation from God, who will never disappoint his servants, though they be sunk to the depth of hell. Although the Church has been forsaken by men, and even by those whom she nourished in her bosom and carried in her arms, yet she shall receive assistance from God. No affliction more severe can befall a mother than to be deserted by her children, who ought in their turn to have treated her with kindness. Such ingratitude and want of natural affection is certainly much liarder to bear than the violent and unbridled cruelty of enemies; for why does she give birth to children, and why does she bring them up, but in expectation of being supported by them in return? Since her children do not perform their duty, what remains but that she shall think that to have born and reared them has been of no advantage to her? Although therefore the Church has performed the duty of a mother, and has brought up her children to the age of maturity, yet the Prophet declares that she must not expect any assistance or consolation from ungrateful persons. Yet his discourse conveys something more, and pronounces those children who have rendered no assistance to their mother to be bastards and reprobates, with the view of inducing her to bear the loss of them more patiently. It was sad and distressing for the Church to be deprived of all her offspring, and to be reduced to childlessness; though this has sometimes happened. But the Prophet reminds the mother that the children do not deserve that she should mourn for them, and that, on the contrary, she ought to desire additional offspring, as it is said by the Psalmist, "The people that shall be created shall praise the Lord." (Psalm 103:18.) What is here described by the Prophet is entirely applicable to our own age; for many boast of being the children of the Church; but where is the man that cares about his mother's distresses? Who is grieved for her ruin? Who is moved so deeply as to put his shoulders to her support? How many betray her, and, under presence of this title, persecute her more cruelly than open and avowed enemies? Accordingly, after all her calamities this is added as the copestone of her miseries. Moreover, they who wish to be regarded as holding the first rank in the Church, and who not only boast of being children, but vaunt of being called fathers, treacherously desert her when she implores their aid. We need not wonder, therefore, if God shall drive them out, in order to make way for the increase of his Church by lawful and dutiful children. [1]

Footnotes

1 - "Afin de donner puis apres a son Eglise des enfans legitimes qui luy assistent." "In order afterwards to give to his Church lawful children to assist her."

There is none to guide her - The image here is taken from the condition of one who is under the influence of an intoxicating draught, and who needs some one to sustain and guide him. The idea is, than among all the inhabitants of Jerusalem in the time of the calamity, there was none who could restore to order the agitated and distracted affairs of the nation. All its wisdom was destroyed; its counsels perplexed; its power overcome.
All the sons whom she hath brought forth - All the inhabitants of Jerusalem.

There is none to guide her among all the sons whom she hath brought forth,.... Still alluding to drunken persons staggering in the streets, that can scarcely stand on their feet, and do not know their way, and yet have none to hold them up and guide them, not even of their friends and relations:
neither is there any that taketh her by the hand of all the sons that she hath brought up; to hold her up from falling, of which there is danger by reeling to and fro, through the intoxicating liquor; and this, either for want of sons, these being dead, or through want of filial affection in them. This was true of Jerusalem, literally understood, at the time of her last destruction by the Romans, when she had no king, priest, nor prophet, to counsel and direct, defend and protect her; and will be the case of the church of God at the slaying of the witnesses, when their own friends will be shy of them, and refuse or neglect to do any kind offices, or show any respect unto them, signified by not suffering their dead bodies to be put into graves, Revelation 11:9.

Following up the image in Isaiah 51:17, intoxicated and confused by the cup of God's anger, she has none to guide her in her helpless state; she has not yet awakened out of the sleep caused by that draught. This cannot apply to the Babylonish captivity; for in it they had Ezekiel and Daniel, Ezra and Nehemiah, as "guides," and soon awoke out of that sleep; but it applies to the Jews now, and will be still more applicable in their coming oppression by Antichrist.

None to guide - When thou wast drunk with this cup, and not able to go.