So went Satan forth from the presence of the LORD, and smote Job with sore boils from the sole of his foot unto his crown.

So Satan went forth from the presence Of the Lord, and struck Job with a very grievous ulcer, from the sole of the foot even to the top of his head:

And Satan went forth from the presence of Jehovah; and he smote Job with a grievous botch from the sole of his foot unto his crown.

And the Adversary goeth forth from the presence of Jehovah, and smiteth Job with a sore ulcer from the sole of his foot unto his crown.

And the Satan went out from before the Lord, and sent on Job an evil disease covering his skin from his feet to the top of his head.

And so, Satan departed from the face of the Lord and he struck Job with a very serious ulcer from the sole of the foot all the way to the crown of his head.

So went Satan forth - Job 1:12.
And smote Job with sore boils - The English word boil denotes the well-known turnout upon the flesh, accompanied with severe inflammation; a sore angry swelling. "Webster." The Hebrew word, however, is in the singular number שׁחין shechı̂yn, and should have been so rendered in our translation. Dr. Good renders it "a burning ulceration." The Vulgate translates it, "ulcere pessimo." The Septuagint, ἕλκει πονηρῶ helkei ponērō - "with a foul ulcer." The Hebrew word שׁחין shechı̂yn means a burning sore; an inflamed ulcer, a bile. "Gesenius." It is derived from שׁכן shâkan, an obsolete root, retained in Arabic, and meaning to be hot or inflamed. It is translated "bile" or "boil," in Exodus 9:9-11; Leviticus 13:18; 2-Kings 20:7;: Isaiah 28:21, (see the notes on that place), Leviticus 13:19-20; Job 2:7; and "botch," Deuteronomy 28:27, Deuteronomy 28:35. The word does not occur elsewhere in the Scriptures. In Deuteronomy 28:27, it means "the botch of Egypt," some species of leprosy, undoubtedly, which prevailed there.
In regard to the disease of Job, we may learn some of its characteristics, not only from the usual meaning of the word, but from the circumstances mentioned in the book itself. It was such that he took a potsherd to scrape himself with, Job 2:8; such as to make his nights restless, and full of tossings to and fro and to clothe his flesh with clods of dust, and with worms, and to break his flesh, or to constitute a running sore or ulcer, Job 7:4-5; such as to make him bite his flesh for pain, Job 13:14, and to make him like a rotten thing, or a garment that is moth eaten, Job 13:28; such that his face was foul with weeping, Job 16:16, and such as to fill him with wrinkles, and to make his flesh lean, Job 16:8; such as to make his breath corrupt, Job 17:1, and his bones cleave to his skin, Job 19:20, Job 19:26; such as to pierce his bones with pain in the night, Job 30:17, and to make his skin black, and to burn up his bones with heat, Job 30:30.
It has been commonly supposed that the disease of Job was a species of black leprosy commonly called "elephantiasis," which prevails much in Egypt. This disease received its name from ἐλέφας elefas, "an elephant," from the swelling produced by it, causing a resemblance to that animal in the limbs; or because it rendered the skin like that of the elephant, scabtons and dark colored. It is called by the Arabs judhām (Dr. Good), and is said to produce in the countenance a grim, distorted, and "lion-like" set of features, and hence has been called by some "Leontiasis." It is known as the black leprosy, to distinguish it from a more common disorder called "white leprosy" - an affection which the Greeks call "Leuce," or "whiteness." The disease of Job seems to have been a universal ulcer; producing an eruption over his entire person, and attended with violent pain, and constant restlessness. A universal bile or groups of biles ever the body would accord with the account of the disease in the various parts of the book. In the elephantiasis the skin is covered with incrustations like those of an elephant. It is a chronic and contagious disease, marked by a thickening of the legs, with a loss of hair and feeling, a swelling of the face, and a hoarse nasal voice. It affects the whole body; the bones as well as the skin are covered with spots and tumors, at first red, but afterward black. "Coxe, Ency. Webster." It should be added that the leprosy in all its forms was regarded as contagious, and of course involved the necessity of a separation from society; and all the circumstances attending this calamity were such as deeply to humble a man of the former rank and dignity of Job.

Sore boils - בשחין רע bischin ra, "with an evil inflammation." What this diabolical disorder was, interpreters are not agreed. Some think it was the leprosy, and this is the reason why he dwelt by himself, and had his habitation in an unclean place, without the city, (Septuagint, εξω της πωλεως), or in the open air: and the reason why his friends beheld him afar off, Job 2:12, was because they knew that the disorder was infectious.
His scraping himself with a potsherd indicates a disease accompanied with intolerable itching, one of the characteristics of the smallpox. Query, Was it not this disorder? And in order to save his life (for that he had in especial command) did not Satan himself direct him to the cool regimen, without which, humanly speaking, the disease must have proved fatal? In the elephantiasis and leprosy there is, properly speaking, no boil or detached inflammation, or swelling, but one uniform disordered state of the whole surface, so that the whole body is covered with loathsome scales, and the skin appears like that of the elephant, thick and wrinkled, from which appearance the disorder has its name. In the smallpox it is different; each pock or pustule is a separate inflammation, tending to suppuration; and during this process, the fever is in general very high, and the anguish and distress of the patient intolerable. When the suppuration is pretty far advanced, the itching is extreme; and the hands are often obliged to be confined to prevent the patient from literally tearing his own flesh.

So went Satan forth from the presence of the LORD, and smote Job with sore (h) boils from the sole of his foot unto his crown.
(h) This sore was most vehement, with which God also plagued the Egyptians, (Exodus 9:9) and threatened to punish rebellious people, (Deuteronomy 28:27) so that this temptation was most grievous: for if Job had measured God's favour by the vehemency of his disease, he might have thought that God had cast him off.

So went Satan forth from the presence of the Lord,.... With leave and license, with power and authority, as the Targum; having got his commission enlarged, on a fresh grant, to do more mischief to Job, he departed directly and immediately, being eager to put in execution what he had a permission to do; See Gill on Job 1:12,
and smote Job with sore boils, from the sole of his foot unto his crown: with hot and burning ulcers, such as were inflicted on the Egyptians in the plague of the boils and blains, called the botch of Egypt, see Exodus 9:10; it is in the original text "with a bad boil", or "the worst" (a); it was as it were but one boil; they stood so thick and close together, that they were as one, reaching from head to foot, and spreading all over his body, so that there was no part free; he was full of sores; as Lazarus, and to him may be applied what is said in a figurative sense of the Jews, Isaiah 1:6; and this boil or boils were of the worst sort, and most hot and angry, and gave the most exquisite pain, and what Job was "smitten" with at once; they did not rise up in pimples and pustules at the first, and gradually gathered and came to an head, but he was at once covered with burning ulcers at their height, and with running sores; this was done by Satan, through divine permission; who, when he has leave, can inflict diseases on the bodies of men, as he did in the days of Christ on earth, see Matthew 17:15; some Jewish writers, as R. Simeon, say, that the devil heated the air, and thereby caused inflammation in Job's blood, which broke out in boils; but then this would have affected others besides him: many are the conjectures of learned men (b) about this disease of Job's, some taking it to be the leprosy (c), others the scurvy, others an erysipelas, &c. Bolducius reckons up no less than fourteen diseases that are attributed to him, collected from his own words, Job 7:5; a late learned writer (d) thinks it was the smallpox.
(a) "nicere malo", Pagninus, Montanus, Piscator, Schmidt; "maligno", Cocceius, Michaelis, "pessimo", Junius & Tremellius, Schultens. (b) Vid. Reiskii dissert. de Morbo Jobi, in Thesaur. Dissert. Philolog. par. 1. p. 556. (c) Origen contr. Cels. l. 6. p. 305. So Michaelis in Lowth. Praelect. de Sacr. Poes. Hebrews. p. 182, 201, 202. (d) Delaney's Life of King David, vol. 2. p. 147.

The devil tempts his own children, and draws them to sin, and afterwards torments, when he has brought them to ruin; but this child of God he tormented with affliction, and then tempted to make a bad use of his affliction. He provoked Job to curse God. The disease was very grievous. If at any time we are tried with sore and grievous distempers, let us not think ourselves dealt with otherwise than as God sometimes deals with the best of his saints and servants. Job humbled himself under the mighty hand of God, and brought his mind to his condition. His wife was spared to him, to be a troubler and tempter to him. Satan still endeavours to draw men from God, as he did our first parents, by suggesting hard thoughts of Him, than which nothing is more false. But Job resisted and overcame the temptation. Shall we, guilty, polluted, worthless creatures, receive so many unmerited blessings from a just and holy God, and shall we refuse to accept the punishment of our sins, when we suffer so much less than we deserve? Let murmuring, as well as boasting, be for ever done away. Thus far Job stood the trial, and appeared brightest in the furnace of affliction. There might be risings of corruption in his heart, but grace had the upper hand.

sore boils--malignant boils; rather, as it is singular in the Hebrew, a "burning sore." Job was covered with one universal inflammation. The use of the potsherd [Job 2:8] agrees with this view. It was that form of leprosy called black (to distinguish it from the white), or elephantiasis, because the feet swell like those of the elephant. The Arabic judham (Deuteronomy 28:35), where "sore botch" is rather the black burning boil (Isaiah 1:6).

The Working Out of the Commission:
7, 8 Then Satan went forth from the presence of Jehovah, and smote Job with sore boils, from the sole of his foot to his crown. And he took him a potsherd to scrape himself with, and sat in the midst of ashes.
The description of this disease calls to mind Deuteronomy 28:35 with Deuteronomy 28:27, and is, according to the symptoms mentioned further on in the book, elephantiasis so called because the limbs become jointless lumps like elephants' legs), Arab. jḏâm, ‛gudhâm, Lat. lepra nodosa, the most fearful form of lepra, which sometimes seizes persons even of the higher ranks. Artapan (C. Mller, Fragm. iii. 222) says, that an Egyptian king was the first man who died of elephantiasis. Baldwin, king of Jerusalem, was afflicted with it in a very dangerous form.
(Note: Vid., the history in Heer, De elephantiasi Graecorum et Arabum, Breslay, 1842, and coloured plates in Trait de la Spdalskhed ou Elephantiasis des Grecs par Danielssen et Boeck, Paris, 1848, translated from the Norwegian; and in Hecker, Elephantiasis oder Lepra Arabica, Lahr, 1858 (with lithographs). "The means of cure," says Aretus the Cappadocian (vid., his writings translated by Mann, 1858, S. 221), "must be more powerful than the disease, if it is to be removed. But what cure can be successfully applied to the fearful evil of elephantiasis? It is not confined to one part, either internally or externally, but takes possession of the entire system. It is terrible and hideous to behold, for it gives a man the appearance of an animal. Every one dreads to live, and have any intercourse, with such invalids; they flee from them as from the plague, for infection is easily communicated by the breath. Where, in the whole range of pharmacy, can such a powerful remedy be found?")
The disease begins with the rising of tubercular boils, and at length resembles a cancer spreading itself over the whole body, by which the body is so affected, that some of the limbs fall completely away. Scraping with a potsherd will not only relieve the intolerable itching of the skin, but also remove the matter. Sitting among ashes is on account of the deep sorrow (comp. Jonah 3:6) into which Job is brought by his heavy losses, especially the loss of his children. The lxx adds that he sat on a dunghill outside the city: the dunghill is taken from the passage Psalm 113:7, and the "outside the city" from the law of the מצרע. In addition to the four losses, a fifth temptation, in the form of a disease incurable in the eye of man, is now come upon Job: a natural disease, but brought on by Satan, permitted, and therefore decreed, by God. Satan does not appear again throughout the whole book. Evil has not only a personal existence in the invisible world, but also its agents and instruments in this; and by these it is henceforth manifested.

Boils - Like those inflicted upon the Egyptians, which are expressed by the same word, and threatened to apostate Israelites, Deuteronomy 28:27, whereby he was made loathsome to himself, and to his nearest relations, and filled with consuming pains in his body, and no less torments and anguish in his mind.