In your patience - Rather by your perseverance. The word "patience" here means constancy or perseverance in sustaining afflictions.
Possess ye your souls - Some read here the "future" instead of the "present" of the verb rendered "possess." The word "possess" means here to "preserve" or keep, and the word "souls" means "lives." This passage may be thus translated: By persevering in bearing these trials you "will" save your lives, or you will be safe; or, by persevering "preserve" your lives; that is, do not yield to these calamities, but bear up under them, for he that endureth to the end, the same shall be saved. Compare Matthew 24:13.

In your patience - Rather, your perseverance, your faithful continuance in my word and doctrine. Ye will preserve your souls. Ye shall escape the Roman sword, and not one of you shall perish in the destruction of Jerusalem. Instead of κτησασθε, possess, or preserve ye, I read κτησεσθε, ye shall preserve. This reading is supported by AB-B, five others; both the Syriac, all the Arabic, Ethiopic, Vulgate, all the Itala except two, Origen, Macarius, and Tertullian.

In your patience (d) possess ye your souls.
(d) Though you are surrounded on all sides with many miseries, yet nonetheless be valiant and courageous, and bear out these things bravely.

In your patience, possess ye your souls. By patiently bearing all afflictions, reproaches, indignities, and persecutions, enjoy yourselves; let nothing disturb or distress you; possess that peace and joy in your souls, which the world cannot take away; see Romans 5:3. The Vulgate Latin, Syriac, Arabic, and Ethiopic versions read, "ye shall possess": and the sense may be this; by patient continuance, or by perseverance in the ways of God, and the truths of Christ unto the end, ye shall be saved; shall find your lives, and enjoy your souls, as in Matthew 10:22.

In your patience possess ye your souls - Be calm and serene, masters of yourselves, and superior to all irrational and disquieting passions. By keeping the government of your spirits, you will both avoid much misery, and guard the better against all dangers.